Issue 5, 2016

Resolution of P-stereogenic P-heterocycles via the formation of diastereomeric molecular and coordination complexes (a review)

Abstract

TADDOL derivatives and the Ca2+-salts of tartaric acid derivatives were found to be versatile and generally applicable resolving agents for the preparation of the enantiomers of P-stereogenic heterocyclic phosphine oxides and phosphinates via the formation of the corresponding diastereomeric molecular and coordination complexes. A few of the diastereomeric intermediates were characterized by single crystal X-ray crystallography to gain insights into the binding mode of the corresponding heterocyclic phosphine oxide (“guest”) and the resolving agent (“host”) and to study the underlying phenomenon of enantiomeric recognition.

Graphical abstract: Resolution of P-stereogenic P-heterocycles via the formation of diastereomeric molecular and coordination complexes (a review)

Article information

Article type
Perspective
Submitted
04 aug 2015
Accepted
29 okt 2015
First published
29 okt 2015
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2016,45, 1823-1842

Author version available

Resolution of P-stereogenic P-heterocycles via the formation of diastereomeric molecular and coordination complexes (a review)

P. Bagi, V. Ujj, M. Czugler, E. Fogassy and G. Keglevich, Dalton Trans., 2016, 45, 1823 DOI: 10.1039/C5DT02999F

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