Issue 25, 2015

Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation

Abstract

Two tetrahydocarbazolone derivatives were found to show multiple unsolvated crystal forms. A persistent dimer motif was detected in solution by FTIR spectroscopy that is maintained in the kinetic crystal forms. Rationally introduced steric bulk induces the formation of a more stable catemeric form.

Graphical abstract: Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation

Supplementary files

Article information

Article type
Communication
Submitted
31 dec 2014
Accepted
10 feb 2015
First published
17 feb 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 5314-5317

Author version available

Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation

R. M. Edkins, E. Hayden, J. W. Steed and K. Fucke, Chem. Commun., 2015, 51, 5314 DOI: 10.1039/C4CC10453F

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