Issue 9, 2014

Synthesis of 1,4-benzodiazepinones and 1,4-benzoxazepinones via palladium-catalyzed amino and oxyacetoxylation

Abstract

Palladium-catalyzed amino and oxyacetoxylation have been developed to furnish 1,4-benzodiazepinones and 1,4-benzoxazepinones through the diheterofunctionalization of alkenes. This study demonstrates the ability of this new methodology to allow 7-exo ring-closure.

Graphical abstract: Synthesis of 1,4-benzodiazepinones and 1,4-benzoxazepinones via palladium-catalyzed amino and oxyacetoxylation

Supplementary files

Article information

Article type
Research Article
Submitted
27 jun 2014
Accepted
19 aug 2014
First published
20 aug 2014

Org. Chem. Front., 2014,1, 1058-1061

Author version available

Synthesis of 1,4-benzodiazepinones and 1,4-benzoxazepinones via palladium-catalyzed amino and oxyacetoxylation

A. D. Manick, G. Duret, D. N. Tran, F. Berhal and G. Prestat, Org. Chem. Front., 2014, 1, 1058 DOI: 10.1039/C4QO00179F

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