Issue 12, 2024

Non-viral vector-based genome editing for cancer immunotherapy

Abstract

Despite the exciting promise of cancer immunotherapy in the clinic, immune checkpoint blockade therapy and T cell-based therapies are often associated with low response rates, intrinsic and adaptive immune resistance, and systemic side effects. CRISPR-Cas-based genome editing appears to be an effective strategy to overcome these unmet clinical needs. As a safer delivery platform for the CRISPR-Cas system, non-viral nanoformulations have been recently explored to target tumor cells and immune cells, aiming to improve cancer immunotherapy on a gene level. In this review, we summarized the efforts of non-viral vector-based CRISPR-Cas-mediated genome editing in tumor cells and immune cells for cancer immunotherapy. Their design rationale and specific applications were highlighted.

Graphical abstract: Non-viral vector-based genome editing for cancer immunotherapy

Article information

Article type
Review Article
Submitted
24 feb 2024
Accepted
25 apr 2024
First published
08 mei 2024

Biomater. Sci., 2024,12, 3068-3085

Non-viral vector-based genome editing for cancer immunotherapy

T. Fang and G. Chen, Biomater. Sci., 2024, 12, 3068 DOI: 10.1039/D4BM00286E

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