Issue 12, 2024

Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting

Abstract

Various strategies at the microscale/nanoscale have been developed to improve oral absorption of therapeutics. Among them, gastrointestinal (GI)-transporter/receptor-mediated nanosized drug delivery systems (NDDSs) have drawn attention due to their many benefits, such as improved water solubility, improved chemical/physical stability, improved oral absorption, and improved targetability of their payloads. Their therapeutic potential in disease animal models (e.g., solid tumors, virus-infected lungs, metastasis, diabetes, and so on) has been investigated, and could be expanded to disease targeting after systemic/lymphatic circulation, although the detailed paths and mechanisms of endocytosis, endosomal escape, intracellular trafficking, and exocytosis through the epithelial cell lining in the GI tract are still unclear. Thus, this review summarizes and discusses potential GI transporters/receptors, their absorption and distribution, in vivo studies, and potential sequential targeting (e.g., oral absorption and disease targeting in organs/tissues).

Graphical abstract: Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting

Supplementary files

Article information

Article type
Review Article
Submitted
29 Feb 2024
Accepted
16 Apr 2024
First published
19 Apr 2024
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2024,12, 3045-3067

Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting

H. Cho, K. M. Huh, H. J. Cho, B. Kim, M. S. Shim, Y. Cho, J. Y. Lee, H. S. Lee, Y. J. Kwon and H. C. Kang, Biomater. Sci., 2024, 12, 3045 DOI: 10.1039/D4BM00313F

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