Issue 56, 2016

Using steric bulk for selective recognition; blocking the binding site to differentiate guests

Abstract

Selectivity is demonstrated in a supramolecular host:guest system using a receptor with a non-linear binding site. For the “open” receptor 1 strong binding for both flexible and rigid guests was observed. Receptor 2, with a “blocked” binding site, also bound flexible guests effectively but its affinity for rigid guests was 50 fold lower.

Graphical abstract: Using steric bulk for selective recognition; blocking the binding site to differentiate guests

Supplementary files

Article information

Article type
Communication
Submitted
31 mei 2016
Accepted
16 jun 2016
First published
16 jun 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 8719-8721

Using steric bulk for selective recognition; blocking the binding site to differentiate guests

R. N. Robson and F. M. Pfeffer, Chem. Commun., 2016, 52, 8719 DOI: 10.1039/C6CC04549A

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