Issue 9, 2023

Concepts, electrode configuration, characterization, and data analytics of electric and electrochemical microfluidic platforms: a review

Abstract

Microfluidic cytometry (MC) and electrical impedance spectroscopy (EIS) are two important techniques in biomedical engineering. Microfluidic cytometry has been utilized in various fields such as stem cell differentiation and cancer metastasis studies, and provides a simple, label-free, real-time method for characterizing and monitoring cellular fates. The impedance microdevice, including impedance flow cytometry (IFC) and electrical impedance spectroscopy (EIS), is integrated into MC systems. IFC measures the impedance of individual cells as they flow through a microfluidic device, while EIS measures impedance changes during binding events on electrode regions. There have been significant efforts to improve and optimize these devices for both basic research and clinical applications, based on the concepts, electrode configurations, and cell fates. This review outlines the theoretical concepts, electrode engineering, and data analytics of these devices, and highlights future directions for development.

Graphical abstract: Concepts, electrode configuration, characterization, and data analytics of electric and electrochemical microfluidic platforms: a review

Article information

Article type
Critical Review
Submitted
13 dec 2022
Accepted
22 feb 2023
First published
23 feb 2023

Analyst, 2023,148, 1912-1929

Concepts, electrode configuration, characterization, and data analytics of electric and electrochemical microfluidic platforms: a review

T. H. Nguyen, H. A. Nguyen, Y. Tran Thi, D. Hoang Tran, H. Cao, T. Chu Duc, T. T. Bui and L. Do Quang, Analyst, 2023, 148, 1912 DOI: 10.1039/D2AN02027K

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