Issue 9, 2023

Reagentless protein-based electrochemical biosensors

Abstract

The creation of reagentless protein-based biosensors that are capable of monitoring molecular analytes directly in bodily fluids could revolutionize our understanding of biology and personalized health monitoring. The limited number of molecular sensors that are currently available in the market depends on the specific enzymatic or chemical reactivity of their target analytes and therefore are not applicable to many relevant biomarkers. Aiming to overcome this limited molecular sensing generality, a new class of reagentless protein-based electrochemical sensors has been introduced for the direct measurements of biomarkers in unprocessed biological fluids. This mini-review will discuss the most recent cutting-edge discoveries for the development of electroanalytical modular biosensors, where all the sensors’ components are integrated into a self-sufficient sensor allowing hence its autonomous functionality.

Graphical abstract: Reagentless protein-based electrochemical biosensors

Article information

Article type
Tutorial Review
Submitted
04 Mar 2023
Accepted
12 Apr 2023
First published
13 Apr 2023

Analyst, 2023,148, 1930-1938

Reagentless protein-based electrochemical biosensors

S. M. Silva, M. Li, A. X. Mendes and S. E. Moulton, Analyst, 2023, 148, 1930 DOI: 10.1039/D3AN00341H

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