Issue 10, 2016

Towards taxane analogues synthesis by dienyne ring closing metathesis

Abstract

Herein we report the facile construction of taxadiene analogues by ring closing metathesis of dienynes built on a cyclohexenone with a natural configuration at C1 and its further transformation to incorporate most of the key functional groups of taxol.

Graphical abstract: Towards taxane analogues synthesis by dienyne ring closing metathesis

Supplementary files

Article information

Article type
Research Article
Submitted
01 ဇူ 2016
Accepted
17 ဩ 2016
First published
18 ဩ 2016

Org. Chem. Front., 2016,3, 1331-1336

Towards taxane analogues synthesis by dienyne ring closing metathesis

S. Pérez-Estrada, N. Sayar and J. R. Granja, Org. Chem. Front., 2016, 3, 1331 DOI: 10.1039/C6QO00321D

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