Issue 2, 2016

Palladium-catalyzed C(sp3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids

Abstract

A Pd-catalyzed arylation of lactic acid employing 8-aminoquinoline as the directing group has been reported. The protocol is found to be compatible with a broad range of synthetically useful functional groups, thus providing a practical route to chiral β-aryl-α-hydroxy acids. Further, the new reaction has also been applied to the synthesis of pharmaceutically important α-hydroxy acids, such as LY519818 and tesaglitazar.

Graphical abstract: Palladium-catalyzed C(sp3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids

Supplementary files

Article information

Article type
Research Article
Submitted
17 အောက် 2015
Accepted
03 ဒီ 2015
First published
07 ဒီ 2015

Org. Chem. Front., 2016,3, 204-208

Palladium-catalyzed C(sp3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids

K. Chen, X. Li, S. Zhang and B. Shi, Org. Chem. Front., 2016, 3, 204 DOI: 10.1039/C5QO00319A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements