Degradation of ZIF-8 in phosphate buffered saline media

Miriam de J. Velásquez-Hernández; Raffaele Ricco; Francesco Carraro; F. Ted Limpoco; Mercedes Linares-Moreau; Erich Leitner; Helmar Wiltsche; Johannes Rattenberger; Hartmuth Schröttner; Philipp Frühwirt; Eduard M. Stadler; Georg Gescheidt; Heinz Amenitsch; Christian J. Doonan; Paolo Falcaro

doi:10.1039/C9CE00757A

Degradation of ZIF-8 in phosphate buffered saline media†

Miriam de J. Velásquez-Hernández,

^a Raffaele Ricco,

^a Francesco Carraro,^a F. Ted Limpoco,^f Mercedes Linares-Moreau,

^a Erich Leitner,

^c Helmar Wiltsche,^c Johannes Rattenberger,^d Hartmuth Schröttner,^d Philipp Frühwirt,^a Eduard M. Stadler,

^a Georg Gescheidt,

^a Heinz Amenitsch,^e Christian J. Doonan

*^b and Paolo Falcaro

*^ab

Author affiliations

* Corresponding authors

^a Institute of Physical and Theoretical Chemistry, Graz University of Technology, 8010 Graz, Austria
E-mail: paolo.falcaro@tugraz.at

^b Department of Chemistry, The University of Adelaide, 5005 Adelaide, South Australia, Australia
E-mail: christian.doonan@adelaide.edu.au

^c Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Graz, Austria

^d Graz Centre for Electron Microscopy (ZFE), 8010 Graz, Austria

^e Institute of Inorganic Chemistry, Graz University of Technology, 8010 Graz, Austria

^f Oxford Instruments GmbH Asylum Research, 65205 Wiesbaden, Germany

Abstract

Understanding the stability of zeolitic imidazolate framework-8 (ZIF-8) under physiological conditions is critical in biotechnology and biomedicine for biosensing, biocatalysis, and drug delivery. The use of ZIF-8 has shown that this metal organic framework (MOF) and its derived bio-composites can degrade in presence of buffer solutions. Here we present an in-depth analysis of the structural and chemical changes of pure ZIF-8 particles exposed to phosphate buffered saline (PBS) media. Two different particle sizes (2 μm and 250 nm) were selected and the decomposition operated by 10 mM PBS (aka 1X) was studied using powder X-ray diffraction (PXRD), Fourier transformed infrared spectroscopy (FTIR), time resolved atomic force microscopy (AFM), in situ small angle X-ray scattering (SAXS), and ³¹P NMR.

This article is part of the themed collections: Introducing the CrystEngComm Advisory Board and their research and Editor’s Collection: Bio-applications of MOFs

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Degradation of ZIF-8 in phosphate buffered saline media†

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