Issue 10, 2016
From the journal:

Organic Chemistry Frontiers

Switching between intermolecular and intramolecular reactions using flow microreactors: lithiation of 2-bromo-2′-silylbiphenyls†

A. Nagaki,*a   S. Kim,a   N. Miuchi,a   H. Yamashita,a   K. Hirosea  and  J. Yoshida*a  

* Corresponding authors

a Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: yoshida@sbchem.kyoto-u.ac.jp, anagaki@sbchem.kyoto-u.ac.jp

Abstract

Reaction-pathway control of 2-lithio-2′-silylbiphenyls was accomplished in flow microreactor systems. Effective switching between the intermolecular reaction with an electrophile and the intramolecular reaction was performed at will by choosing an appropriate residence time and temperature region.

Graphical abstract: Switching between intermolecular and intramolecular reactions using flow microreactors: lithiation of 2-bromo-2′-silylbiphenyls

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Article information

DOI
https://doi.org/10.1039/C6QO00257A
Article type
Research Article
Submitted
09 ဇွန် 2016
Accepted
25 ဇူ 2016
First published
26 ဇူ 2016

Org. Chem. Front., 2016,3, 1250-1253

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Switching between intermolecular and intramolecular reactions using flow microreactors: lithiation of 2-bromo-2′-silylbiphenyls

A. Nagaki, S. Kim, N. Miuchi, H. Yamashita, K. Hirose and J. Yoshida, Org. Chem. Front., 2016, 3, 1250 DOI: 10.1039/C6QO00257A

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