Issue 31, 2021

Mechanism of Pd-catalysed C(sp3)–H arylation of thioethers with Ag(i) additives

Abstract

Mechanistic studies reveal that Pd-catalyzed C(sp3)–H arylation of thioethers with silver(I) additives takes place via C(sp3)–H activation, oxidative addition and reductive elimination, wherein all steps proceed via the heterodimeric Pd–Ag pathway. Besides, the active heterodimeric Pd–Ag species are detected by mass spectrometry via control experiments.

Graphical abstract: Mechanism of Pd-catalysed C(sp3)–H arylation of thioethers with Ag(i) additives

Supplementary files

Article information

Article type
Communication
Submitted
11 Apr. 2021
Accepted
14 Jūl. 2021
First published
14 Jūl. 2021

Org. Biomol. Chem., 2021,19, 6766-6770

Mechanism of Pd-catalysed C(sp3)–H arylation of thioethers with Ag(I) additives

W. Liu, Z. Liu, X. Liu and Y. Dang, Org. Biomol. Chem., 2021, 19, 6766 DOI: 10.1039/D1OB00704A

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