Issue 66, 2021

Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling

Abstract

The construction of the cyclopropyl quaternary carbon center can afford a series of 1,1-olefin bioisosteres. Here, we report tertiary cyclopropyl carbagermatranes, which can be easily obtained by the zinc-mediated decarboxylation of NHP esters. In addition, they exhibit efficient reactivity in the palladium-catalyzed cross-coupling reaction and orthogonal reactivity with boron reagents, therefore acting as robust nucleophiles for the synthesis of tertiary cyclopropane and efficient intermediates for the formation of quaternary centers.

Graphical abstract: Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling

Supplementary files

Article information

Article type
Communication
Submitted
03 Jūn. 2021
Accepted
07 Jūl. 2021
First published
27 Jūl. 2021

Chem. Commun., 2021,57, 8143-8146

Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling

S. Yang, W. Jiang and B. Xiao, Chem. Commun., 2021, 57, 8143 DOI: 10.1039/D1CC02930D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements