Issue 10, 2019

Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

Abstract

The marilones and marilines are a new family of polyketide metabolites recently isolated from the marine-derived fungus Stachylidium sp. 293K04. They are characterized by a phthalide and phthalimidine skeleton, respectively. From a series of feeding experiments using 13C-labeled precursors we could outline the biogenetic origin of the basic carbon skeleton of marilone A and mariline B. Results established the tetraketide nature of the phthalide/phthalimidine nucleus including the involvement of a methylated acetate starter unit in polyketide biosynthesis, which is unique amongst fungal metabolites.

Graphical abstract: Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

Supplementary files

Article information

Article type
Paper
Submitted
25 Janv. 2019
Accepted
14 Febr. 2019
First published
14 Febr. 2019

Org. Biomol. Chem., 2019,17, 2747-2752

Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

F. El Maddah, E. Eguereva, S. Kehraus and G. M. König, Org. Biomol. Chem., 2019, 17, 2747 DOI: 10.1039/C9OB00198K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements