Issue 40, 2015

Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis

Abstract

The spatiotemporal coordination of angiogenesis in synthetic materials is important for mimicking natural tissue morphogenesis. Here we report patterned hydrogel encapsulation of mesenchymal stem cells to direct endothelial tubulogenesis in co-culture. Tubulogenesis occurs preferentially over MSC patterns, suggesting this strategy may prove useful in guiding the design of heterotypic engineered tissues.

Graphical abstract: Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis

Supplementary files

Article information

Article type
Communication
Submitted
30 Jūn. 2015
Accepted
06 Aug. 2015
First published
06 Aug. 2015

J. Mater. Chem. B, 2015,3, 7896-7898

Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis

A. A. Abdeen, J. Lee, S. H. Mo and K. A. Kilian, J. Mater. Chem. B, 2015, 3, 7896 DOI: 10.1039/C5TB01294E

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