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Issue 40, 2015
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Strategies for skeletal muscle tissue engineering: seed vs. soil

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The most commonly used tissue engineering approach includes the ex vivo combination of site-appropriate cell(s) and scaffold material(s) to create three-dimensional constructs for tissue replacement or reconstruction. These three-dimensional combinations are typically subjected to a period of culture and conditioning (i.e., self-assembly and maturation) to promote the development of ex vivo constructs which closely mimic native target tissue. This cell-based approach is challenged by the host response to the engineered tissue construct following surgical implantation. As an alternative to the cell-based approach, acellular biologic scaffolds attract endogenous cells and remodel into partially functional mimics of native tissue upon implantation. The present review examines cell-types (i.e., seed), scaffold materials (i.e., soil), and challenges associated with functional tissue engineering. Skeletal muscle is used as the target tissue prototype but the discussed principles will largely apply to most body systems.

Graphical abstract: Strategies for skeletal muscle tissue engineering: seed vs. soil

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Publication details

The article was received on 20 Aug 2015, accepted on 08 Sep 2015 and first published on 17 Sep 2015

Article type: Review Article
DOI: 10.1039/C5TB01714A
Citation: J. Mater. Chem. B, 2015,3, 7881-7895

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    Strategies for skeletal muscle tissue engineering: seed vs. soil

    B. M. Sicari, R. Londono and S. F. Badylak, J. Mater. Chem. B, 2015, 3, 7881
    DOI: 10.1039/C5TB01714A

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