Issue 71, 2015

Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms

Abstract

Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the biofilms. Moreover, this class of membrane-active molecules disarms the development of bacterial resistance.

Graphical abstract: Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
23 Jūn. 2015
Accepted
20 Jūl. 2015
First published
21 Jūl. 2015

Chem. Commun., 2015,51, 13670-13673

Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms

J. Hoque, M. M. Konai, S. Samaddar, S. Gonuguntala, G. B. Manjunath, C. Ghosh and J. Haldar, Chem. Commun., 2015, 51, 13670 DOI: 10.1039/C5CC05159B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements