Issue 3, 2024

Mass filtering combined with photochemical derivatization enables high throughput mass spectrometric analysis of unsaturated phosphatidylcholine isomers

Abstract

Phosphatidylcholines (PCs) are closely related to coronary heart disease, such as myocardial infarction. The analysis of the deep structure of PCs is of great significance for exploring the effects of exercise rehabilitation and lipid metabolism. Here, we present a mass filtering combined with photochemical derivatization method for rapid screening and accurate identification of the C[double bond, length as m-dash]C position and sn-location isomer of PCs. This method is simple to execute and easily implementable for routine analysis. The accurate qualitative and quantitative analysis of PCs and isomers facilitates the discovery of biomarkers for exercise rehabilitation of patients with myocardial infarction.

Graphical abstract: Mass filtering combined with photochemical derivatization enables high throughput mass spectrometric analysis of unsaturated phosphatidylcholine isomers

Supplementary files

Article information

Article type
Communication
Submitted
15 Okt. 2023
Accepted
06 Nov. 2023
First published
07 Nov. 2023

Anal. Methods, 2024,16, 371-377

Mass filtering combined with photochemical derivatization enables high throughput mass spectrometric analysis of unsaturated phosphatidylcholine isomers

H. Li, Q. Xiong, H. Wu, Y. Zhang, K. Zhuang, Y. Zhao, H. Zhang and L. Yi, Anal. Methods, 2024, 16, 371 DOI: 10.1039/D3AY01829F

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