Issue 10, 2021

Activatable fluorescence sensors for in vivo bio-detection in the second near-infrared window

Abstract

Fluorescence imaging in the second near-infrared (NIR-II, 1000–1700 nm) window has exhibited advantages of high optical resolution at deeper penetration (ca. 5–20 mm) in bio-tissues owing to the reduced photon scattering, absorption and tissue autofluorescence. However, the non-responsive and “always on” sensors lack the ability of selective imaging of lesion areas, leading to the low signal-to-background ratio (SBR) and poor sensitivity during bio-detection. In contrast, activatable sensors show signal variation in fluorescence intensity, spectral wavelength and fluorescence lifetime after responding to the micro-environment stimuli, leading to the high detection sensitivity and reliability in bio-sensing. This minireview summarizes the design and detection ability of recently reported NIR-II activatable sensors. Furthermore, the challenges, opportunities and prospects of NIR-II activatable bio-sensing are also discussed.

Graphical abstract: Activatable fluorescence sensors for in vivo bio-detection in the second near-infrared window

Article information

Article type
Minireview
Submitted
31 Aug. 2020
Accepted
11 Nov. 2020
First published
12 Nov. 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2021,12, 3448-3459

Activatable fluorescence sensors for in vivo bio-detection in the second near-infrared window

M. Zhao, B. Li, H. Zhang and F. Zhang, Chem. Sci., 2021, 12, 3448 DOI: 10.1039/D0SC04789A

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