Issue 44, 2021

Acridinone-based anion transporters

Abstract

The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven to be a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea motif which had previously shown promise as an anion sensor and expand the series of compounds by appending a variety of electron-withdrawing groups to the peripheral phenyl moieties. High levels of activity were achieved by the most effective compounds in the series, which facilitated strictly electroneutral transport.

Graphical abstract: Acridinone-based anion transporters

Supplementary files

Article information

Article type
Paper
Submitted
06 Aug. 2021
Accepted
01 Sept. 2021
First published
13 Sept. 2021

Org. Biomol. Chem., 2021,19, 9659-9674

Acridinone-based anion transporters

D. A. McNaughton, L. K. Macreadie and P. A. Gale, Org. Biomol. Chem., 2021, 19, 9659 DOI: 10.1039/D1OB01545A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements