Issue 15, 2021

Standardisation needs for organ on chip devices

Abstract

Organ on chip (OoC) devices represent the cutting edge of biotechnologies, combining advanced cell and tissue culture with microengineering. OoC is accelerating innovation in the life sciences and has the potential to revolutionise many fields including biomedical research, drug development and chemical risk assessment. In order to gain acceptance by end-users of OoC based methods and the data derived from them, and to establish OoC approaches as credible alternatives to animal testing, OoC devices need to go through an extensive qualification process. In this context, standardisation can play a key role in ensuring proper characterisation of individual devices, benchmarking against appropriate reference elements and aiding efficient communication among stakeholders. The development of standards for OoC will address several important issues such as basic terminology, device classification, and technical and biological performance. An analysis of technical and biological aspects related to OoC is presented here to identify standardisation areas specific for OoC, focusing on needs and opportunities. About 90 standards are already available from related fields including microtechnologies, medical devices and in vitro cell culture, laying the basis for future work in the OoC domain. Finally, two priority areas for OoC are identified that could be addressed with standards, namely, characterisation of small molecule absorption and measurement of microfluidic parameters.

Graphical abstract: Standardisation needs for organ on chip devices

Supplementary files

Article information

Article type
Perspective
Submitted
25 Marts 2021
Accepted
17 Jūn. 2021
First published
12 Jūl. 2021
This article is Open Access
Creative Commons BY license

Lab Chip, 2021,21, 2857-2868

Standardisation needs for organ on chip devices

M. Piergiovanni, S. B. Leite, R. Corvi and M. Whelan, Lab Chip, 2021, 21, 2857 DOI: 10.1039/D1LC00241D

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