Issue 37, 2019

Helical supramolecular polymer nanotubes with wide lumen for glucose transport: towards the development of functional membrane-spanning channels

Abstract

The manipulation of strong noncovalent interactions provides a concise and versatile strategy for constructing highly ordered supramolecular structures. By using a shape-persistent building block consisting of phenanthroline derivatives and two quadruply hydrogen-bonding AADD moieties, a type of precise helical supramolecular polymer (HSP) nanotube has been developed. The helical conformation of the supramolecular polymers has been proved via various techniques, showing significantly expanded topologies of supramolecular polymers. From the production of new topological structures of supramolecular polymers, predictable properties and functions have arisen. In this study, the helical folding of supramolecular polymers gave rise to the generation of specific wide lumen structures that can be directly visualized via TEM, and the resulting HSP nanotubes can puncture the lipid bilayer membrane to facilitate the transportation of glucose.

Graphical abstract: Helical supramolecular polymer nanotubes with wide lumen for glucose transport: towards the development of functional membrane-spanning channels

Supplementary files

Article information

Article type
Edge Article
Submitted
13 Maijs 2019
Accepted
29 Jūl. 2019
First published
30 Jūl. 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 8648-8653

Helical supramolecular polymer nanotubes with wide lumen for glucose transport: towards the development of functional membrane-spanning channels

C. Zhang, X. Deng, C. Wang, C. Bao, B. Yang, H. Zhang, S. Qi and Z. Dong, Chem. Sci., 2019, 10, 8648 DOI: 10.1039/C9SC02336D

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