Issue 13, 2019

Synthesis of dihydroquinolinones via iridium-catalyzed cascade C–H amidation and intramolecular aza-Michael addition

Abstract

An iridium-catalyzed annulation of chalcones with sulfonyl azides via cascade C–H amidation and intramolecular aza-Michael addition was developed, affording a variety of 2-aryl-2,3-dihydro-4-quinolones in moderate to good yields. This reaction features easy operation, readily available starting materials, and the cascade formation of two C–N bonds in one pot.

Graphical abstract: Synthesis of dihydroquinolinones via iridium-catalyzed cascade C–H amidation and intramolecular aza-Michael addition

Supplementary files

Article information

Article type
Communication
Submitted
09 Dec. 2018
Accepted
18 Janv. 2019
First published
18 Janv. 2019

Chem. Commun., 2019,55, 1915-1918

Synthesis of dihydroquinolinones via iridium-catalyzed cascade C–H amidation and intramolecular aza-Michael addition

C. Pan, Z. Yang, H. Xiong, J. Teng, Y. Wang and J. Yu, Chem. Commun., 2019, 55, 1915 DOI: 10.1039/C8CC09751H

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