Issue 22, 2018

Photoredox-catalyzed indirect acyl radical generation from thioesters

Abstract

A photoredox-catalyzed method for the indirect generation of acyl radicals from stable thioesters is described. The process is applicable to both aromatic and aliphatic substrates, and the resulting acyl radicals can undergo both intermolecular and intramolecular reactions. The mild reaction conditions allow for domino photoredox-catalyzed processes to occur. To illustrate the utility of the method, the total synthesis of a pharmaceutical agent is described.

Graphical abstract: Photoredox-catalyzed indirect acyl radical generation from thioesters

Supplementary files

Article information

Article type
Research Article
Submitted
13 Aug. 2018
Accepted
04 Okt. 2018
First published
05 Okt. 2018

Org. Chem. Front., 2018,5, 3267-3298

Photoredox-catalyzed indirect acyl radical generation from thioesters

A. R. Norman, M. N. Yousif and C. S. P. McErlean, Org. Chem. Front., 2018, 5, 3267 DOI: 10.1039/C8QO00867A

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