Copper-catalyzed aminotrifluoromethylation of alkenes: a facile synthesis of CF3-containing lactams

Abstract

Copper-catalyzed aminotrifluoromethylation of alkenes using amides as nucleophiles has been developed. It provides a rapid and efficient access to a variety of CF₃-containing lactams. The reaction proceeds under mild conditions with a good scope and functional group tolerance, offering a valuable method to prepare CF₃-containing lactams that are of great potential in pharmaceuticals and agrochemicals.