Issue 31, 2016

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

Abstract

Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived.

Graphical abstract: Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

  • This article is part of the themed collection: Foldamers

Supplementary files

Article information

Article type
Communication
Submitted
29 Febr. 2016
Accepted
11 Marts 2016
First published
24 Marts 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 5421-5424

Author version available

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

G. M. Burslem, H. F. Kyle, A. L. Breeze, T. A. Edwards, A. Nelson, S. L. Warriner and A. J. Wilson, Chem. Commun., 2016, 52, 5421 DOI: 10.1039/C6CC01812B

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