Issue 60, 2015

Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification

Abstract

Strategies that confine antibacterial and/or antifouling property to the surface of the implant, by modifying the surface chemistry and morphology or by encapsulating the material in an antibiotic-loaded coating, are most promising as they do not alter bulk integrity of the material. Among them, plasma-assisted modification and catechol chemistry stand out for their ability to modify a wide range of substrates. By controlling processing parameters, plasma environment can be used for surface nano structuring, chemical activation, and deposition of biologically active and passive coatings. Catechol chemistry can be used for material-independent, highly-controlled surface immobilisation of active molecules and fabrication of biodegradable drug-loaded hydrogel coatings. In this article, we comprehensively review the role plasma-assisted processing and catechol chemistry can play in combating bacterial colonisation on medically relevant coatings, and how these strategies can be coupled with the use of natural antimicrobial agents to produce synthetic antibiotic-free antibacterial surfaces.

Graphical abstract: Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification

Article information

Article type
Review Article
Submitted
30 Dec. 2014
Accepted
21 Maijs 2015
First published
21 Maijs 2015
This article is Open Access
Creative Commons BY license

RSC Adv., 2015,5, 48739-48759

Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification

K. Bazaka, M. V. Jacob, W. Chrzanowski and K. Ostrikov, RSC Adv., 2015, 5, 48739 DOI: 10.1039/C4RA17244B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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