Issue 25, 2023

A fluorescent probe based on an enhanced ICT effect for Hg2+ detection and cell imaging

Abstract

The mercury ion (Hg2+) has hindered society to some extent due to its high biological toxicity, and a rapid method for Hg2+ detection is urgently needed. In the present work, two fluorescent probes, YF-Hg and YF-Cl-Hg, were developed. YF-Cl-Hg was produced by introducing an electron-withdrawing substituent (–Cl) into the structure of YF-Hg. The probe YF-Cl-Hg possesses a larger Stokes shift and a more pronounced UV-vis absorption redshift compared to YF-Hg in a pH = 7.4 environment. The reasons for the superior spectral performance of YF-Cl-Hg over YF-Hg were explored by density functional theory (DFT) calculations and UV-vis absorption spectroscopy. Furthermore, the good biocompatibility suggests that YF-Cl-Hg possesses the potential to be a tool for Hg2+ detection in cells.

Graphical abstract: A fluorescent probe based on an enhanced ICT effect for Hg2+ detection and cell imaging

Supplementary files

Article information

Article type
Paper
Submitted
11 Apr. 2023
Accepted
23 Maijs 2023
First published
23 Maijs 2023

Anal. Methods, 2023,15, 3026-3033

A fluorescent probe based on an enhanced ICT effect for Hg2+ detection and cell imaging

S. Pei, C. Li, X. Pei, X. Zhang, Y. Chi, W. Zeng, Y. Zhang, X. Liao and J. Chen, Anal. Methods, 2023, 15, 3026 DOI: 10.1039/D3AY00544E

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