Issue 48, 2021

Nongenetic control of receptor signaling dynamics using a DNA-based optochemical tool

Abstract

Optochemical tools that can modulate the activity of the target protein provide an opportunity for studying and regulating the related biological processes. Here we present a DNA-based nongenetic optochemical tool that can control the dynamics of growth factor signaling. This photo-caged mimicry of growth factor can be a promising tool for elucidating a linkage between the dynamics of signaling and the resulting biological outcomes, as well as for manipulating cellular functions and the fate of living cells.

Graphical abstract: Nongenetic control of receptor signaling dynamics using a DNA-based optochemical tool

Supplementary files

Article information

Article type
Communication
Submitted
13 Apr. 2021
Accepted
14 Maijs 2021
First published
15 Maijs 2021

Chem. Commun., 2021,57, 5969-5972

Author version available

Nongenetic control of receptor signaling dynamics using a DNA-based optochemical tool

R. Ueki, S. Hayashi, M. Tsunoda, M. Akiyama, H. Liu, T. Ueno, Y. Urano and S. Sando, Chem. Commun., 2021, 57, 5969 DOI: 10.1039/D1CC01968F

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