Issue 10, 2015

Deep eutectic solvent based on choline chloride and malonic acid as an efficient and reusable catalytic system for one-pot synthesis of functionalized pyrroles

Abstract

A deep eutectic solvent (DES) based on choline chloride and malonic acid was prepared easily with high purity at a low cost. It has been applied as a dual catalyst and reaction medium for the synthesis of functionalized pyrroles by a one-pot, four-component reaction of amines, aldehydes, 1,3-dicarbonyl compounds and nitromethane. This green solvent could be recycled and reused three times without loss of its efficiency.

Graphical abstract: Deep eutectic solvent based on choline chloride and malonic acid as an efficient and reusable catalytic system for one-pot synthesis of functionalized pyrroles

Supplementary files

Article information

Article type
Paper
Submitted
01 Nov. 2014
Accepted
19 Dec. 2014
First published
22 Dec. 2014

RSC Adv., 2015,5, 7720-7728

Author version available

Deep eutectic solvent based on choline chloride and malonic acid as an efficient and reusable catalytic system for one-pot synthesis of functionalized pyrroles

H. Hu, Y. Liu, B. Li, Z. Cui and Z. Zhang, RSC Adv., 2015, 5, 7720 DOI: 10.1039/C4RA13577F

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