Issue 21, 2020

Evaluating medical device and material thrombosis under flow: current and emerging technologies

Abstract

Although blood-contacting medical devices are used widely, blood clot formation (thrombosis) leads to device failure and potentially catastrophic adverse thrombotic events for patients, such as stroke or pulomonary embolism. Systemic anti-thrombotic drugs aimed at reducing these complications do not always prevent device thrombosis and can cause increased bleeding risks. Therefore, our understanding of material thrombosis mechanisms needs to be improved in order to develop next generation blood-contacting medical devices and materials. Medical device development requires material thrombogenicity evaluation according to the International Standards 10993-4 Biological evaluation of medical devicesSelection of tests for interactions with blood, which highlights that one of the key aspects for testing is a clinically relevant flow system. In this review, we first provide an overview of the current knowledge regarding material thrombosis and important physical and biological aspects of blood flow in relation to thrombus formation. We then examine commonly used in vitro flow systems to evaluate material and medical device thrombosis, focusing on their capabilities, advantages and disadvantages. Finally, we explore recent advances in technology that will aid in improving the design and fabrication of flow systems, mechanistic analysis and computational modelling.

Graphical abstract: Evaluating medical device and material thrombosis under flow: current and emerging technologies

Article information

Article type
Review Article
Submitted
02 Aug 2020
Accepted
30 Sep 2020
First published
12 Okt 2020

Biomater. Sci., 2020,8, 5824-5845

Evaluating medical device and material thrombosis under flow: current and emerging technologies

J. K. Hong, L. Gao, J. Singh, T. Goh, A. M. Ruhoff, C. Neto and A. Waterhouse, Biomater. Sci., 2020, 8, 5824 DOI: 10.1039/D0BM01284J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements