Issue 71, 2015

Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms

Abstract

Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the biofilms. Moreover, this class of membrane-active molecules disarms the development of bacterial resistance.

Graphical abstract: Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
23 Iun 2015
Accepted
20 Quint 2015
First published
21 Quint 2015

Chem. Commun., 2015,51, 13670-13673

Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms

J. Hoque, M. M. Konai, S. Samaddar, S. Gonuguntala, G. B. Manjunath, C. Ghosh and J. Haldar, Chem. Commun., 2015, 51, 13670 DOI: 10.1039/C5CC05159B

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