Recent developments in the synthesis and applications of furopyrazoles

Abstract

This review aims to describe the different strategies developed so far for the synthesis of furo[2,3-c]pyrazole, furo[3,2-c]pyrazole, dihydrofuro[2,3-c]pyrazole, dihydrofuro[3,4-c]pyrazole tetrahydrofuro[3,4-c]pyrazole, tetrahydrofuro[3,2-c]pyrazole, hexahydrofuro[3,4-c]pyrazole, furo-di-pyrazole and bis-furopyrazole derivatives and their biological and pharmacological properties such as antiallergic effects, anticancer, antibacterial, antifungal, antimicrobial, and anti-leukemia activities, high affinity to CB₂ receptors, high σ₁ receptor affinity and antioxidant activities. Owing to this diversity in the biological field, they have attracted the attention of many researchers to study their synthetic methods and biological activities. Our research efforts have been focusing on different aspects of furopyrazole derivatives including facile synthesis and investigating their bioactivity.