Themed collection World Cancer Day 2024: Showcasing cancer research across the RSC

45 items
Highlight

Polyprodrugs for tumor chemotherapy: from molecular structure to drug release performance

The structure–property relationship of polyprodrugs was explored from the perspective of molecular structure, by discussing the effects of the conjugations and linkers on their drug content and drug releasing performance.

Graphical abstract: Polyprodrugs for tumor chemotherapy: from molecular structure to drug release performance
From the themed collection: Biomedical Polymer Materials
Open Access Perspective

Perspective of point-of-care sensing systems in cancer management

Revolutionizing cancer management: point-of-care sensing systems in perspective.

Graphical abstract: Perspective of point-of-care sensing systems in cancer management
Review Article

Sonocatalytic cancer therapy: theories, advanced catalysts and system design

Sonocatalytic cancer therapy has emerged as a promising strategy through the combination of ultrasound waves and catalytic materials to selectively target and destroy cancer cells.

Graphical abstract: Sonocatalytic cancer therapy: theories, advanced catalysts and system design
From the themed collection: Nanoscale 2024 Emerging Investigators
Open Access Review Article

Prospects of nanoparticle-based radioenhancement for radiotherapy

Inorganic nanomaterials show promising potential for radiotherapy enhancement. This article provides a concise summary of mechanisms involved, materials designs and future prospects of nanoparticle-based radioenhancement for precision medicine.

Graphical abstract: Prospects of nanoparticle-based radioenhancement for radiotherapy
Open Access Review Article

Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial photothermal therapy

Injectable hydrogels intended for cancer combinatorial-photothermal therapy bring forward the possibility of attaining multifunctional systems for an improved and selective treatment for this disease.

Graphical abstract: Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial photothermal therapy
From the themed collection: Injectable Hydrogels
Review Article

3D bioprinting complex models of cancer

Cancer is characterized by the uncontrolled division of cells, resulting in the formation of tumors. The personalized composition of biomaterials and 3D techniques can be used as a modelling tool to understand the complexity of various cancers.

Graphical abstract: 3D bioprinting complex models of cancer
Review Article

Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications

In the past few years, the development in the construction and architecture of graphene based nanocomplexes has dramatically accelerated the use of nano-graphene for therapeutic and diagnostic purposes, fostering a new area of nano-cancer therapy.

Graphical abstract: Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications
Open Access Critical Review

Recent advances in PAMAM dendrimer-based CT contrast agents for molecular imaging and theranostics of cancer

Recent advances and some key developments in the construction of PAMAM dendrimer-based nanoplatforms for tumor CT imaging and theranostics have been reviewed.

Graphical abstract: Recent advances in PAMAM dendrimer-based CT contrast agents for molecular imaging and theranostics of cancer
Open Access Critical Review

Diagnosis of cancer using carbon nanomaterial-based biosensors

Basic principle of sensing technique of various carbon nanomaterial-based biosensors.

Graphical abstract: Diagnosis of cancer using carbon nanomaterial-based biosensors
Open Access Communication

Re-engineered theranostic gold nanoparticles for targeting tumor hypoxia

Developing nanovehicles for selective delivery of a radiation dose/drug to hypoxic tumors is a present-day clinical requirement for effective treatment of cancer.

Graphical abstract: Re-engineered theranostic gold nanoparticles for targeting tumor hypoxia
Communication

Self-reported and self-facilitated theranostic oxygen nano-economizer for precise and hypoxia alleviation-potentiated photodynamic therapy

A self-reported and self-facilitated theranostic oxygen nano-economizer (PTTD NPs) for precise photodynamic therapy (PDT) is developed. Under self-reported optimal laser duration, PTTD NPs could alleviate tumor hypoxia for self-facilitating PDT.

Graphical abstract: Self-reported and self-facilitated theranostic oxygen nano-economizer for precise and hypoxia alleviation-potentiated photodynamic therapy
Communication

A biocompatible pure organic porous nanocage for enhanced photodynamic therapy

A biocompatible porphyrin-based pure organic porous nanocage with large cavity, high porosity as well as enhanced type I and type II reactive oxygen species generation is developed for photodynamic therapy.

Graphical abstract: A biocompatible pure organic porous nanocage for enhanced photodynamic therapy
Communication

Cell membrane-specific self-assembly of peptide nanomedicine induces tumor immunogenic death to enhance cancer therapy

A strategy of cell membrane-specific self-assembly based on peptide nanomedicine is developed to induce tumor immunogenic death in cancer therapy.

Graphical abstract: Cell membrane-specific self-assembly of peptide nanomedicine induces tumor immunogenic death to enhance cancer therapy
Communication

Tumor-microenvironment-responsive poly-prodrug encapsulated semiconducting polymer nanosystem for phototherapy-boosted chemotherapy

Phototherapy-induced hypoxia boosts the chem-therapy of PEG-TPZ for enhanced theranostics.

Graphical abstract: Tumor-microenvironment-responsive poly-prodrug encapsulated semiconducting polymer nanosystem for phototherapy-boosted chemotherapy
Open Access Communication

HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex

HER-2 targeted boron nitride nanotube was developed as a boron agent for boron neutron capture therapy.

Graphical abstract: HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex
Open Access Communication

Ultrafast sensitivity-controlled and specific detection of extracellular vesicles using optical force with antibody-modified microparticles in a microflow system

We propose a detection method of 103–104 nanoscale extracellular vesicles secreted from cancer cells and distinguish their multiple membrane proteins using controlled optical force and microfluidic pressure only by 5 minutes laser irradiation.

Graphical abstract: Ultrafast sensitivity-controlled and specific detection of extracellular vesicles using optical force with antibody-modified microparticles in a microflow system
From the themed collection: 2023 Horizons Outstanding Paper Award Winners
Open Access Communication

Rapid identification of molecular subtyping of breast cancer cell lines using a multi-channel sensor array

A multi-channel sensor array composed of three fluorescent units is constructed to differentiate and identify molecular subtypes of breast cancer.

Graphical abstract: Rapid identification of molecular subtyping of breast cancer cell lines using a multi-channel sensor array
Communication

Carbonic anhydrase IX-targeted nanovesicles potentiated ferroptosis by remodeling the intracellular environment for synergetic cancer therapy

This work demonstrated a nanovesicle-potentiated ferroptosis by remodeling the tumor intracellular environment, providing a promising paradigm for designing nanomedicines to heighten ferroptosis-based synergetic therapeutics.

Graphical abstract: Carbonic anhydrase IX-targeted nanovesicles potentiated ferroptosis by remodeling the intracellular environment for synergetic cancer therapy
Communication

Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung diseases

A nanostrategy that combines bright core–shell probes, a nanomixing chip, and machine learning was proposed to evaluate the clinical performance of plasma EV phenotypes in differentiating early-stage lung cancer and benign lung diseases.

Graphical abstract: Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung diseases
Open Access Communication

Discrimination between protein glycoforms using lectin-functionalised gold nanoparticles as signal enhancers

Biolayer interferometry is used to distinguish between glycoforms of the same using lectin-functional nanoparticles as both readers, and signal enhancers. The use of this is exemplified with prostate specific antigen.

Graphical abstract: Discrimination between protein glycoforms using lectin-functionalised gold nanoparticles as signal enhancers
Open Access Paper

Cationic dextrin nanoparticles for effective intracellular delivery of cytochrome C in cancer therapy

Intracellular protein delivery using cationic dextrin nanoparticles show promise as a selective and specific approach to cancer therapy.

Graphical abstract: Cationic dextrin nanoparticles for effective intracellular delivery of cytochrome C in cancer therapy
Paper

AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors

Comparison of click chemistry and sortagging grafting strategies for functionalizing AGuIX nanoparticles with nanobodies to develop a tri-functional technology combining MRI imaging, radiotherapy, and immunotherapy by inhibiting immune checkpoints.

Graphical abstract: AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors
Open Access Paper

Targeted photodynamic therapy for breast cancer: the potential of glyconanoparticles

Glyconanoparticles selectively bind to cellular targets via glycan–lectin interactions and are excellent drug-delivery systems for targeted photodynamic therapy of cancer.

Graphical abstract: Targeted photodynamic therapy for breast cancer: the potential of glyconanoparticles
Open Access Paper

Ultra-small platinum-based coordination nanoparticles for radiotherapy

Two novel nanoparticles based on Pt-containing coordination networks, produced by a green method, reveal important radioenhancement activity on cancerous cells.

Graphical abstract: Ultra-small platinum-based coordination nanoparticles for radiotherapy
Paper

Bismuth nanoclusters on nitrogen-doped porous carbon nanoenzyme for cancer therapy

We have designed a highly efficient bismuth nanocluster supported on nitrogen-doped porous carbon as a nanozyme (Bi-NC) for cancer therapy. At the same time, Bi-NC shows good photothermal conversion performance to generate heat for strengthening the therapy.

Graphical abstract: Bismuth nanoclusters on nitrogen-doped porous carbon nanoenzyme for cancer therapy
Open Access Paper

Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model

Dual magneto-chemotherapeutic effects on a 3D breast cancer model after 10, 20 and 30 min of treatment.

Graphical abstract: Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model
From the themed collection: Theranostic nanoplatforms for biomedicine
Open Access Paper

Thymoquinone-loaded lipid nanocapsules with promising anticancer activity for colorectal cancer

Lipid nanocapsules was used as thymoquinone nano delivery system to treat colorectal cancer (CRC). TQ-LNCs show a suitable mean size particle and a high drug payload, inducing an early decrease in tumor growth following intratumoral administration to mice.

Graphical abstract: Thymoquinone-loaded lipid nanocapsules with promising anticancer activity for colorectal cancer
Paper

Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment

A biodegradable COF was constructed to break in response to tumors, enhancing the therapeutic effect on tumors.

Graphical abstract: Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment
From the themed collection: Biomedical Polymer Materials
Open Access Paper

Photophysical and biological assessment of coumarin-6 loaded polymeric nanoparticles as a cancer imaging agent

Coumarin-6 is used as a model hydrophobic drug to investigate delivery to tumors via polymeric micelles. Photophysical characterization, as well as in vitro and in vivo experiments showcase this platform for cancer diagnosis and imaging.

Graphical abstract: Photophysical and biological assessment of coumarin-6 loaded polymeric nanoparticles as a cancer imaging agent
Paper

In vivo targeting of a tumor-antigen encoded DNA vaccine to dendritic cells in combination with tumor-selective chemotherapy eradicates established mouse melanoma

Eradicating established mouse melanoma by tumor-selective chemotherapy in combination with in vivo dendritic cell targeted genetic immunization using a tumor antigen encoded DNA vaccine.

Graphical abstract: In vivo targeting of a tumor-antigen encoded DNA vaccine to dendritic cells in combination with tumor-selective chemotherapy eradicates established mouse melanoma
Open Access Paper

A mitochondria-targeted chemiluminescent probe for detection of hydrogen sulfide in cancer cells, human serum and in vivo

Mitochondria-targeted chemiluminescent probe MCH enables visualization of hydrogen sulfide activity in cancer cells, human serum, and animal models.

Graphical abstract: A mitochondria-targeted chemiluminescent probe for detection of hydrogen sulfide in cancer cells, human serum and in vivo
Open Access Paper

An anti-glioblastoma gold(I)–NHC complex distorts mitochondrial morphology and bioenergetics to induce tumor growth inhibition

A new gold(I)-based therapeutic strategy to treat glioblastoma multiforme (GBM).

Graphical abstract: An anti-glioblastoma gold(i)–NHC complex distorts mitochondrial morphology and bioenergetics to induce tumor growth inhibition
From the themed collection: Chemical Biology of Metals
Open Access Paper

Structural and molecular insight into antibody recognition of dynamic neoepitopes in membrane tethered MUC1 of pancreatic cancer cells and secreted exosomes

We unveil for the first time that pancreatic cancer cells (PANC-1) and secreted exosomes express MUC1 bearing cancer-relevant dynamic epitopes recognized specifically by an anti-MUC1 antibody (SN-131).

Graphical abstract: Structural and molecular insight into antibody recognition of dynamic neoepitopes in membrane tethered MUC1 of pancreatic cancer cells and secreted exosomes
Paper

Construction of Fe-doped ZIF-8/DOX nanocomposites for ferroptosis strategy in the treatment of breast cancer

The DOX@7FZ was able to enhance the ROS level in cancer cells via a synergistic effect between apoptosis/ferroptosis synergism.

Graphical abstract: Construction of Fe-doped ZIF-8/DOX nanocomposites for ferroptosis strategy in the treatment of breast cancer
Open Access Paper

Redox double-switch cancer theranostics through Pt(IV) functionalised manganese dioxide nanostructures

A new redox-responsive double-switch cancer theranostic was developed based on Mn nanostructures and a Pt prodrug. The ability of these probes to respond to altered redox states was validated in 2/3D cell models and in a preclinical mouse model.

Graphical abstract: Redox double-switch cancer theranostics through Pt(iv) functionalised manganese dioxide nanostructures
Paper

Evaluating glioblastoma tumour sphere growth and migration in interaction with astrocytes using 3D collagen-hyaluronic acid hydrogels

Glioblastoma cells co-cultured with astrocytes in col-HA hydrogels exhibit changes in migration patterns. 3D in vitro models using ECM mimetic materials can be used to analyze glioma-astrocyte crosstalk.

Graphical abstract: Evaluating glioblastoma tumour sphere growth and migration in interaction with astrocytes using 3D collagen-hyaluronic acid hydrogels
Paper

Erythrocyte membrane-camouflaged DNA-functionalized upconversion nanoparticles for tumor-targeted chemotherapy and immunotherapy

We report the new biomimetic nanoparticles, which is the synergistic combination of immunogenic cell death inducer and immunoadjuvant, proving to be the unique strategy to successfully induce an immune response and boost the anticancer response.

Graphical abstract: Erythrocyte membrane-camouflaged DNA-functionalized upconversion nanoparticles for tumor-targeted chemotherapy and immunotherapy
Paper

Polypropylene sulphide coating on magnetic nanoparticles as a novel platform for excellent biocompatible, stimuli-responsive smart magnetic nanocarriers for cancer therapeutics

Magnetic nanoparticle delivery systems are promising for targeted drug delivery, imaging, and chemo-hyperthermia of cancer; but their toxicity from reactive oxygen species generation, targeted delivery, and biodegradation limits their use.

Graphical abstract: Polypropylene sulphide coating on magnetic nanoparticles as a novel platform for excellent biocompatible, stimuli-responsive smart magnetic nanocarriers for cancer therapeutics
Open Access Paper

Iron nitroprusside as a chemodynamic agent and inducer of ferroptosis for ovarian cancer therapy

A schematic representation of FeNP-induced ROS production and its involvement in ferroptosis.

Graphical abstract: Iron nitroprusside as a chemodynamic agent and inducer of ferroptosis for ovarian cancer therapy
Paper

Tumor-targeted molybdenum disulfide@barium titanate core–shell nanomedicine for dual photothermal and chemotherapy of triple-negative breast cancer cells

Intracellular working mechanism of Gem-loaded MBPF CSNPs when exposed to NIR laser irradiation. MBPF passively targets and enhances ROS generation and DNA damage within MDA-MB-231 cells through their dual performance.

Graphical abstract: Tumor-targeted molybdenum disulfide@barium titanate core–shell nanomedicine for dual photothermal and chemotherapy of triple-negative breast cancer cells
Open Access Paper

Zn doped iron oxide nanoparticles with high magnetization and photothermal efficiency for cancer treatment

The substitution of Fe2+ ions by Zn2+ ions in the crystal lattice of ferrites increases both the nanoparticles magnetization, and their photothermal conversion efficiency.

Graphical abstract: Zn doped iron oxide nanoparticles with high magnetization and photothermal efficiency for cancer treatment
Research Article

Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis via inhibiting Src in hepatocellular carcinoma cells

When the purine analog, compound 19, is introduced to liver cancer cells, selectively interacting with ALK and BTK, phospho-Src, phospho-Rb, cyclin E, and cdk2 levels decrease, thereby leading the cell to apoptosis.

Graphical abstract: Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis via inhibiting Src in hepatocellular carcinoma cells
Research Article

Novel pyrazolo[3,4-d]pyrimidine derivatives: design, synthesis, anticancer evaluation, VEGFR-2 inhibition, and antiangiogenic activity

A novel series of 12 pyrazolo[3,4-d]pyrimidine derivatives were created and evaluated in vitro for their antiproliferative activity against the NCI 60 human tumor cell line panel.

Graphical abstract: Novel pyrazolo[3,4-d]pyrimidine derivatives: design, synthesis, anticancer evaluation, VEGFR-2 inhibition, and antiangiogenic activity
Open Access Research Article

Discovery of pyrazolopyrimidines that selectively inhibit CSF-1R kinase by iterative design, synthesis and screening against glioblastoma cells

Compound libraries synthesised and screened against glioma cells built up structure–antiproliferative activity–relationships and informed further design, synthesis and screening, resulting in the discovery of potent CSF-1R inhibitors.

Graphical abstract: Discovery of pyrazolopyrimidines that selectively inhibit CSF-1R kinase by iterative design, synthesis and screening against glioblastoma cells
Research Article

Dual FLT3/haspin kinase inhibitor based on 3H-pyrazolo[4,3-f]quinoline scaffold with activities against acute myeloid leukemia

The 3H-pyrazolo[4,3-f]quinoline core, a privileged fusion moiety from quinoline and indazole, facilely synthesized in a one flask multi-component Doebner–Povarov reaction, is a newly described kinase hinge binder.

Graphical abstract: Dual FLT3/haspin kinase inhibitor based on 3H-pyrazolo[4,3-f]quinoline scaffold with activities against acute myeloid leukemia
45 items

About this collection

In line with World Cancer Day on 4 February 2024, this post-publication collection showcases just some of the exciting cancer research published in various RSC journals through 2023. From developing sensors and diagnostic techniques to drug delivery and investigating treatments such as radiotherapy, photodynamic therapy and chemotherapy, this collection aims to highlight recent developments in efforts to understand cancer and ways to provide effective treatments. The RSC is proud to play a part in disseminating such important research and we hope you enjoy reading some of the latest articles and reviews in this collection.

Spotlight

Advertisements