Themed collection Proteomics

Inductive reasoning has been the corner stone of a large plethora of proteomics investigations, shifting the a priori paradigm of classical cellular and molecular biology to the experimental observation of protein modulation. These studies are now providing better definitions of their application framework.

Peptide-centric bottom-up proteomics can lead to ambiguous results.

Supraphysiological doses of doping agents, such as T/DHT and GH/IGF-1, affect cellular pathways associated with apoptosis and inflammation.

The proteomic study of pediatric brain tumors tissues by top-down/bottom-up platforms revealed different expression profiles and potential malignancy biomarkers.

The chemical composition of the cervical mucus (CM), its physical characteristics and the volume of secretion change cyclically throughout the menstrual cycle.

The cytotoxic mechanisms of the organogold(III) Aubipy_c.

Set-up of a specific protocol for membrane protein analysis, applied to label free, comparative proteomics of renal cell carcinoma microdomains.

The protein identified here may offer a new insight into deciphering damage caused by cigarette smoke.

Proteomic analysis of the protein expression profiles of enriched mitochondrial preparations of rat INS-1E β cells treated with palmitate in the presence and in the absence of GLP-1.

Borrelia and Francisella interact differently with complement regulatory proteins from various hosts, which influences the disease development and ecology of pathogens.

We examine and compare the protein adsorption capacity and coagulation profiles of different haemodialysis membrane biomaterials.

Characterization of two types of stem cells isolated from human amniotic fluid.

NO exposure of two human high grade glioma cell lines (CCF-STTG1 and T98G) characterized by a different proteomic profile shows differential ceramide distribution and proliferation.

Repeatability of the ¹⁵N metabolic labeling workflow for quantitative proteomics in mouse plasma and brain specimens.

Reversible redox modifications of the microglial proteome contribute to switching of these neuronal sentinel cells toward a neuroinflammatory phenotype.

First proteomic characterization of sonic hedgehog human medulloblastoma stem-like cells.

Bladder cancer is estimated to be the ninth most common malignancy with a high rate of recurrence and progression despite therapy, early diagnosis being crucial for timely intervention.

A combined proteomic and metabolomic approach revealed new non-apoptotic roles of the metacaspase YCA1 gene in Saccharomyces cerevisiae, highlighting its involvement in the cell metabolism and stress response.

This paper highlights the importance of metabolic profiling by LC-MS/MS and GC-MS of biological fluids for diagnosis of inborn errors of metabolism and confirms a high incidence of these disorders.

(1) Lipid profiling in MuS and OND patients. (2) Search of alterations associated with MuS. (3) Characterization of differences.

Salivary proteomic investigation in SAPHO syndrome reveals significant variation of cystatins, histatins, aPRP, S100A12, suggesting their potential role as biomarkers.

Discovery of early urinary biomarkers for Fabry disease in male and female adult patients revealed by proteomics.

A simple and rapid technique for construction of single domain antibody (V_HH) library for ribosome display is described in this study.

The paper shows a new method for the application of Matrix Assisted Laser Desorption/Ionisation (MALDI) Mass Spectrometry Imaging (MSI) technology on formalin-fixed paraffin-embedded (FFPE) tissue samples.