Issue 70, 2022

Design of high-avidity multivalent ligand structures that target cells with high ligand economy

Abstract

Novel cell-targeting ligand structures are constructed with a spikey core scaffold, where multiple copies of coiled-coil peptide nanorods are conjugated on the surface of a peptide nanosheet. Clustering of carbohydrate and aptamer ligands at the end of the coiled coils optimizes ligand accessibility to cell-surface receptors. Display of the ligand-coil conjugates on the nanosheet generates a patchy ligand pattern bearing two levels of multivalency. With the ligand-scaffold system, high-avidity cell targeting is realized using fewer ligands than ever, which facilitates future applications in cell detection and drug delivery.

Graphical abstract: Design of high-avidity multivalent ligand structures that target cells with high ligand economy

Supplementary files

Article information

Article type
Communication
Submitted
11 6 2022
Accepted
08 8 2022
First published
08 8 2022

Chem. Commun., 2022,58, 9802-9805

Design of high-avidity multivalent ligand structures that target cells with high ligand economy

Q. Fang, P. Guo, Y. Zeng, C. Wang, T. Jiang and Y. Jiang, Chem. Commun., 2022, 58, 9802 DOI: 10.1039/D2CC03296A

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