Issue 39, 2021

Cation-chloride cotransport mediated by an ion pair transporter

Abstract

Ion transport mediated by an ion pair receptor 1 bearing both cation and anion binding sites is presented. The ion pair binding property was revealed by means of 1H NMR titrations in organic solutions and X-ray analysis in the solid state. Single crystal structures demonstrated that 1 and CaI2 formed a solvent-separated ion-pair complex with two iodides each interacting with a triazine ring through anion–π interactions, whereas the calcium ion is bound by a pentaethylene glycol moiety. The ion transport activity was studied by monitoring the efflux of ions from salt-loaded EYPC large unilamellar vesicles (EYPC-LUVs) using ion selective electrodes. Chloride transport across the membrane mediated by the ion pair receptor through K+/Cl or Na+/Cl cotransport with a selectivity towards the K+/Cl symport was realized.

Graphical abstract: Cation-chloride cotransport mediated by an ion pair transporter

Supplementary files

Article information

Article type
Paper
Submitted
17 8 2021
Accepted
15 9 2021
First published
15 9 2021

Org. Biomol. Chem., 2021,19, 8586-8590

Cation-chloride cotransport mediated by an ion pair transporter

J. Zhu, X. Wang, J. Luo, Y. Ao, Q. Wang and D. Wang, Org. Biomol. Chem., 2021, 19, 8586 DOI: 10.1039/D1OB01617B

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