Issue 10, 2015

RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies

Abstract

Malignant primary brain tumors are aggressive cancerous cells that invade the surrounding tissues of the central nervous system. The current treatment options for malignant brain tumors are limited due to the inability to cross the blood–brain barrier. The advancements in current research has identified and characterized certain molecular markers that are essential for tumor survival, progression, metastasis and angiogenesis. These molecular markers have served as therapeutic targets for the RNAi based therapies, which enable site-specific silencing of the gene responsible for tumor proliferation. However, to bring about therapeutic success, an efficient delivery carrier that can cross the blood–brain barrier and reach the targeted site is essential. The current review focuses on the potential of targeted, non-viral and viral particles containing RNAi therapeutic molecules as delivery strategies specifically for brain tumors.

Graphical abstract: RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies

Article information

Article type
Review Article
Submitted
20 4 2015
Accepted
23 6 2015
First published
25 6 2015

Mol. BioSyst., 2015,11, 2635-2657

Author version available

RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies

M. Malhotra, A. Toulouse, B. M. D. C. Godinho, D. J. Mc Carthy, J. F. Cryan and C. M. O'Driscoll, Mol. BioSyst., 2015, 11, 2635 DOI: 10.1039/C5MB00278H

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