Issue 37, 2024

Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device

Abstract

A heart-on-a-particle model based on multicompartmental microgel is proposed to simulate the heart microenvironment and study the cardiotoxicity of drugs. The relevant microgel was fabricated by a biocompatible microfluidic-based approach, where heart function-related HL-1 and HUVEC cells were arranged in separate compartments. Finally, the mechanism of aconitine-induced heart toxicity was elucidated using mass spectrometry and molecular biotechnology.

Graphical abstract: Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device

Supplementary files

Article information

Article type
Communication
Submitted
26 1 2024
Accepted
27 3 2024
First published
28 3 2024

Chem. Commun., 2024,60, 4898-4901

Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device

T. Xu, Z. Wu, H. Yao, Y. Zhang, S. Chen, Y. Li, X. Meng, Y. Zhang and J. Lin, Chem. Commun., 2024, 60, 4898 DOI: 10.1039/D4CC00396A

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