Issue 37, 2024

Accessing pyrrolo[1,2-a]indole derivatives via visible-light-induced dearomatizative cyclization of indoles

Abstract

Pyrrolo[1,2-a]indoles are structurally important scaffolds in many natural products and bioactive compounds. Herein, we report a novel synthetic method for pyrrolo[1,2-a]indole derivatives through visible-light-induced cascade dearomatizative cyclization of indoles with external nucleophiles. Moderate yields, good diastereoselectivities, and excellent regioselectivities were generally observed with the resultant indole-fused polycyclic compounds.

Graphical abstract: Accessing pyrrolo[1,2-a]indole derivatives via visible-light-induced dearomatizative cyclization of indoles

Supplementary files

Article information

Article type
Communication
Submitted
16 Mar 2024
Accepted
09 Apr 2024
First published
10 Apr 2024

Chem. Commun., 2024,60, 4902-4905

Accessing pyrrolo[1,2-a]indole derivatives via visible-light-induced dearomatizative cyclization of indoles

Z. Liu, X. Ji, L. Duan, G. Deng and H. Huang, Chem. Commun., 2024, 60, 4902 DOI: 10.1039/D4CC01215A

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