Issue 43, 2021

Medicinal chemistry inspired by ginger: exploring the chemical space around 6-gingerol

Abstract

Ginger (Zingiber officinale Roscoe) has been used as a spice and as a traditional remedy since ancient times, especially in traditional Chinese medicine. It has been applied as a treatment for many diseases either alone or in combination with other remedies. Many studies were conducted on ginger and its constituents and a wide array of bioactivities were reported, e.g., antioxidant, anti-inflammatory, antiemetic, and anticancer activity. Most of these had been correlated to gingerols and shogaols, the most abundant secondary metabolites in ginger. This inspired several research groups to explore the biomedical value of the chemical space around these compounds, and many of their synthetic or semi-synthetic analogues have been prepared and studied for various bioactivities. Thanks to this, many valuable structure activity relationships have been revealed for such compounds. Herein, we provide a brief summary on the synthetic derivatization efforts that had so far been implemented on 6-gingerol, the main constituent of fresh ginger. This review covers 160 natural, semisynthetic, or synthetic 6-gingerol derivatives and their reported bioactivities.

Graphical abstract: Medicinal chemistry inspired by ginger: exploring the chemical space around 6-gingerol

Article information

Article type
Review Article
Submitted
31 5 2021
Accepted
24 7 2021
First published
04 8 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 26687-26699

Medicinal chemistry inspired by ginger: exploring the chemical space around 6-gingerol

S. H. H. Ahmed, T. Gonda and A. Hunyadi, RSC Adv., 2021, 11, 26687 DOI: 10.1039/D1RA04227K

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