Issue 81, 2018

Cyanomethyl anion transfer reagents for diastereoselective Corey–Chaykovsky cyclopropanation reactions

Abstract

A readily available and bench-stable cyanomethyl sulfonium salt was used in highly diastereoselective Corey–Chaykovsky cyclopropanation reactions of electron-poor olefins. This efficient method provides a rapid route to access densely functionalized cyclopropyl nitriles.

Graphical abstract: Cyanomethyl anion transfer reagents for diastereoselective Corey–Chaykovsky cyclopropanation reactions

Supplementary files

Article information

Article type
Communication
Submitted
11 7 2018
Accepted
20 9 2018
First published
20 9 2018

Chem. Commun., 2018,54, 11439-11442

Cyanomethyl anion transfer reagents for diastereoselective Corey–Chaykovsky cyclopropanation reactions

R. Hommelsheim, K. J. Hock, C. Schumacher, M. A. Hussein, T. V. Nguyen and R. M. Koenigs, Chem. Commun., 2018, 54, 11439 DOI: 10.1039/C8CC05602A

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