Issue 9, 2017

Temporal switching of an amphiphilic self-assembly by a chemical fuel-driven conformational response

Abstract

The spatial and temporal control of self-assemblies is the latest scientific hurdle in supramolecular chemistry which is inspired by the functioning of biological systems fueled by chemical signals. In this study, we work towards alleviating this scenario by employing a unique amphiphilic foldamer that operates under the effect of a chemical fuel. The conformational changes in the foldamer amplify into observable morphological changes in its amphiphilic assembly that are controlled by external molecular cues (fuel). We take advantage of this redox responsive foldamer to affect its conformation in a temporal manner by an enzymatic pathway. The temporal characteristics of the transient conformation/assembly can be modulated by varying the concentrations of the fuel and enzyme. We believe that such a design strategy can have positive consequences in designing molecular and supramolecular systems for future active, adaptive and autonomous materials.

Graphical abstract: Temporal switching of an amphiphilic self-assembly by a chemical fuel-driven conformational response

Supplementary files

Article information

Article type
Edge Article
Submitted
19 4 2017
Accepted
10 7 2017
First published
11 7 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 6030-6036

Temporal switching of an amphiphilic self-assembly by a chemical fuel-driven conformational response

K. Jalani, S. Dhiman, A. Jain and S. J. George, Chem. Sci., 2017, 8, 6030 DOI: 10.1039/C7SC01730H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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