Issue 5, 2017

Synthesis, utility and medicinal importance of 1,2- & 1,4-dihydropyridines

Abstract

Dihydropyridine (DHP) is among the most beneficial scaffolds that have revolutionised pharmaceutical research with unprecedented biological properties. Over the years, metamorphosis of easily accessible 1,2- and 1,4-dihydropyridine (1,4-DHP) intermediates by synthetic chemists has generated several drug molecules and natural products such as alkaloids. The 1,4-dihydropyridine (1,4-DHP) moiety itself is the main fulcrum of several approved drugs. The present review aims to collate the literature of 1,2- and the 1,4-DHPs relevant to synthetic and medicinal chemists. We will describe various methodologies that have been used for the synthesis of this class of compounds, including the strategies which can furnish enantiopure DHPs, either by asymmetric synthesis or by chiral resolution. We will also elaborate the significance of DHPs towards the synthesis of natural products of medicinal merit.

Graphical abstract: Synthesis, utility and medicinal importance of 1,2- & 1,4-dihydropyridines

Article information

Article type
Review Article
Submitted
06 10 2016
Accepted
14 11 2016
First published
12 1 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 2682-2732

Synthesis, utility and medicinal importance of 1,2- & 1,4-dihydropyridines

V. K. Sharma and S. K. Singh, RSC Adv., 2017, 7, 2682 DOI: 10.1039/C6RA24823C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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