Issue 50, 2013

Locked nucleic acid: tighter is different

Abstract

This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity and specificity of LNA, and these provide the main focus of the viewpoint.

Graphical abstract: Locked nucleic acid: tighter is different

Article information

Article type
Viewpoint
Submitted
15 1 2013
Accepted
10 5 2013
First published
16 5 2013

Chem. Commun., 2013,49, 5618-5620

Locked nucleic acid: tighter is different

J. K. Watts, Chem. Commun., 2013, 49, 5618 DOI: 10.1039/C3CC40340H

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