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Issue 50, 2013
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11CO2 fixation: a renaissance in PET radiochemistry

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Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide. Most carbon-11 labels, however, are installed using derivative reagents generated from [11C]CO2. In recent years, [11C]CO2 has seen a revival in applications for the direct incorporation of carbon-11 into functional groups such as ureas, carbamates, oxazolidinones, carboxylic acids, esters, and amides. This review summarizes classical [11C]CO2 fixation strategies using organometallic reagents and then focuses on newly developed methods that employ strong organic bases to reversibly capture [11C]CO2 into solution, thereby enabling highly functionalized labelled compounds to be prepared. Labelled compounds and radiopharmaceuticals that have been translated to the clinic are highlighted.

Graphical abstract: 11CO2 fixation: a renaissance in PET radiochemistry

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Article information

27 Mar 2013
01 May 2013
First published
01 May 2013

Chem. Commun., 2013,49, 5621-5629
Article type
Feature Article

11CO2 fixation: a renaissance in PET radiochemistry

B. H. Rotstein, S. H. Liang, J. P. Holland, T. L. Collier, J. M. Hooker, A. A. Wilson and N. Vasdev, Chem. Commun., 2013, 49, 5621
DOI: 10.1039/C3CC42236D

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