Issue 13, 2015

The synthesis and characterisation of strontium and calcium folates with potential osteogenic activity

Abstract

Compounds having the general formula MFO·4H2O where M = Ca or Sr and FO = a folate anion were prepared and their structure and physico-chemical properties were determined by elemental and thermal TGA, DSC analysis, FTIR, and EDAX spectroscopies and DRX. The results indicate that the two compounds form stable structures where folic acid acts as a self-bridging ligand via two bidentate carboxylate groups. Moreover the two compounds showed a low toxicity in vitro response as h-osteoblast cell viability was not negatively affected by the presence of folate derivatives within the range of 0.063–0.5 mg ml−1. The results also indicate that the folate derivatives that are formed overcome the toxic effects related to free Sr2+ ions. The range of maximum cell viability corresponding with a concentration of SrFO falls within the in vitro physiologically active range for strontium while within the same range the strontium derivative showed a potential osteogenic activity as indicated by the overexpression of ALP activity.

Graphical abstract: The synthesis and characterisation of strontium and calcium folates with potential osteogenic activity

Article information

Article type
Paper
Submitted
27 11 2014
Accepted
16 2 2015
First published
16 2 2015

J. Mater. Chem. B, 2015,3, 2708-2713

Author version available

The synthesis and characterisation of strontium and calcium folates with potential osteogenic activity

L. Rojo, S. Radley-Searle, M. Fernandez-Gutierrez, L. M. Rodriguez-Lorenzo, C. Abradelo, S. Deb and J. San Roman, J. Mater. Chem. B, 2015, 3, 2708 DOI: 10.1039/C4TB01969E

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