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Issue 13, 2015
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Haemolytic activity and cellular toxicity of SBA-15-type silicas: elucidating the role of the mesostructure, surface functionality and linker length

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Abstract

In this contribution, amorphous silica (a-SiO2), native SBA-15 silica as well as four functional SBA-15-type silicates modified with aminopropyl (SBA-NH2), mercaptopropyl (SBA-SH), ethylcarboxylic (SBA-COOH) and undecenoic acid (SBA-FA-COOH) were prepared by the co-condensation route under similar self-assembly and sol–gel conditions. Next, the impact of these materials on red blood cells was evaluated by studying cell haemolysis and haemoglobin adsorption. Moreover, the influence of the presence of human serum albumin (HSA) on erythrocyte haemolysis and cytotoxicity toward B14 Chinese fibroblasts were investigated. Based on these variants, the role of the mesostructure, the nature of the functional group located on the silica surface and the influence of the linker length have been elucidated.

Graphical abstract: Haemolytic activity and cellular toxicity of SBA-15-type silicas: elucidating the role of the mesostructure, surface functionality and linker length

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Publication details

The article was received on 18 Nov 2014, accepted on 26 Jan 2015 and first published on 27 Jan 2015


Article type: Paper
DOI: 10.1039/C4TB01901F
Citation: J. Mater. Chem. B, 2015,3, 2714-2724

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    Haemolytic activity and cellular toxicity of SBA-15-type silicas: elucidating the role of the mesostructure, surface functionality and linker length

    M. Ferenc, N. Katir, K. Miłowska, M. Bousmina, J. Majoral, M. Bryszewska and A. El Kadib, J. Mater. Chem. B, 2015, 3, 2714
    DOI: 10.1039/C4TB01901F

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