Themed collection Most popular 2023 analytical chemistry articles
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Polymeric materials for ultrasound imaging and therapy
Ultrasound-responsive polymeric materials with finely tunable physicochemical properties and acoustic responses enable their applications in imaging and therapy, such as functional/molecular imaging, targeted drug delivery, and sonopermeation.
Chem. Sci., 2023,14, 11941-11954
https://doi.org/10.1039/D3SC04339H
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Time- and angle-resolved photoemission spectroscopy (TR-ARPES) of TMDC monolayers and bilayers
Many unique properties in two-dimensional (2D) materials and their heterostructures rely on charge excitation, scattering, transfer and relaxation dynamics across different points in the momentum space.
Chem. Sci., 2023,14, 736-750
https://doi.org/10.1039/D2SC04124C
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Engineered aptamers for molecular imaging
Molecular imaging, including quantification and molecular interaction studies, plays a crucial role in visualizing and analysing molecular events. Aptamers are wildly employed in molecular imaging with a wide range of targets and imaging modalities.
Chem. Sci., 2023,14, 14039-14061
https://doi.org/10.1039/D3SC03989G
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Surface-enhanced Raman scattering sensing for detection and mapping of key cellular biomarkers
The principles and advantages of SERS sensing strategies including multi-modal analysis for detection or mapping of key cellular biomarkers are described in this review.
Chem. Sci., 2023,14, 12869-12882
https://doi.org/10.1039/D3SC04650H
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Polarizing agents for efficient high field DNP solid-state NMR spectroscopy under magic-angle spinning: from design principles to formulation strategies
More than two decades of research have established fundamental principles for the rational design of increasingly efficient polarization sources for DNP MAS NMR.
Chem. Sci., 2023,14, 6120-6148
https://doi.org/10.1039/D3SC01079A
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Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives
This review presents the recent advances in SARS-CoV-2 detection, including molecular diagnostics, antigen and antibody testing, and advances assay of neutralizing antibodies and emerging variants.
Chem. Sci., 2023,14, 6149-6206
https://doi.org/10.1039/D2SC06665C
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Critical assessment of selenourea as an efficient small molecule fluorescence quenching probe to monitor protein dynamics
This work unravels that reduced ΔE and higher −ve ΔG of the electron transfer reaction are crucial for an ultrafast intrinsic photoinduced electron transfer (PET) process that enables selenourea (SeU) as an efficient fluorescence quenching probe.
Chem. Sci., 2023,14, 14200-14210
https://doi.org/10.1039/D3SC04287A
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Biocatalytic reductive amination as a route to isotopically labelled amino acids suitable for analysis of large proteins by NMR
We demonstrate an atom-efficient and easy to use H2-driven biocatalytic platform for the enantioselective synthesis of isotopically labelled amino acids for protein NMR studies.
Chem. Sci., 2023,14, 12160-12165
https://doi.org/10.1039/D3SC01718D
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Mild and scalable synthesis of phosphonorhodamines
First reported in the 1800s, rhodamines have become indispensable fluorophores for biological imaging. We report a new, high-yielding synthesis of water soluble-rhodamines with a phosphonic acid instead of the traditional carboxylate.
Chem. Sci., 2023,14, 11365-11373
https://doi.org/10.1039/D3SC02590J
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Post-synthetic benzylation of the mRNA 5′ cap via enzymatic cascade reactions
Novel S-adenosyl-L-methionine analogues were generated enzymatically and used for regioselective benzylation of biomolecules. Applied to the mRNA 5′ cap, protein production in cells can be increased and immunogenicity altered.
Chem. Sci., 2023,14, 10962-10970
https://doi.org/10.1039/D3SC03822J
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A high-field cellular DNP-supported solid-state NMR approach to study proteins with sub-cellular specificity
We show that the polarising agent SNAPol-1 enters human cells yielding 800 MHz DNP solid-state NMR data of remarkable sensitivity & resolution thereby revealing structural heterogeneity of ubiquitin at atomic scale and with sub-cellular specificity.
Chem. Sci., 2023,14, 9892-9899
https://doi.org/10.1039/D3SC02117C
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Responsive calcium-derived nanoassemblies induce mitochondrial disorder to promote tumor calcification
A dual-path metabolic destruction-assisted therapeutic strategy by sequentially inducing apoptosis and prompting calcification of tumor cells.
Chem. Sci., 2023,14, 9350-9359
https://doi.org/10.1039/D3SC02945J
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Combining native mass spectrometry and lipidomics to uncover specific membrane protein–lipid interactions from natural lipid sources
While it is known that lipids play an essential role in regulating membrane protein structure and function, it remains challenging to identify specific protein–lipid interactions.
Chem. Sci., 2023,14, 8570-8582
https://doi.org/10.1039/D3SC01482G
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Chemical sensors for imaging total cellular aliphatic aldehydes in live cells
We introduce “turn-on” non-toxic fluorescent sensors as a diagnostic tool to rapidly detect and quantify total aliphatic aldehyde levels in live cells.
Chem. Sci., 2023,14, 8305-8314
https://doi.org/10.1039/D3SC02025H
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A highly sensitive nanochannel device for the detection of SUMO1 peptides
Current techniques could not accurately identify SUMO1, here we report a cyclic peptide with strong affinity toward SUMO1, the immobilization of CP on the nanochannel constructs a highly sensitive and specific device for detecting SUMO1 peptides.
Chem. Sci., 2023,14, 8360-8368
https://doi.org/10.1039/D3SC02140H
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Improving time-resolution and sensitivity of in situ X-ray photoelectron spectroscopy of a powder catalyst by modulated excitation
Modulated excitation experiments coupled to time-resolved NAP-XPS allow following the dynamics of reactive species on a powder Pd/Al2O3 catalyst with unprecedented precision..
Chem. Sci., 2023,14, 7482-7491
https://doi.org/10.1039/D3SC01274C
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A near-infrared light-activatable Ru(II)-coumarin photosensitizer active under hypoxic conditions
The preparation of a novel hypoxia-active Ru(II)-coumarin photosensitizer with advantageous luminescent and biocompatible properties for near-infrared anticancer photodynamic therapy is described.
Chem. Sci., 2023,14, 7170-7184
https://doi.org/10.1039/D3SC01844J
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Chemiluminescent duplex analysis using phenoxy-1,2-dioxetane luminophores with color modulation
Chemiluminescence phenoxy-1,2-dioxetane luminophores for multiplex analysis of enzymes and bioanalytes.
Chem. Sci., 2023,14, 6953-6962
https://doi.org/10.1039/D3SC02386A
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Molecular-level degradation pathways of black phosphorus revealed by mass spectrometry fingerprinting
Black phosphorus (BP) can generate intrinsic phosphorus cluster fingerprint peaks in LDI-MS in both positive- and negative-ion modes, which allows the degradation pathways of BP to be unraveled at the molecular level without any chemical labeling.
Chem. Sci., 2023,14, 6669-6678
https://doi.org/10.1039/D2SC06297F
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Unprecedented perspectives on the application of CinNapht fluorophores provided by a “late-stage” functionalization strategy
A simple and easy-to-implement process based on a nucleophilic aromatic substitution reaction with a wide variety of nucleophiles on a fluorinated CinNapht offers unprecedented perspectives.
Chem. Sci., 2023,14, 6000-6010
https://doi.org/10.1039/D3SC01365K
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AI facilitated fluoro-electrochemical phytoplankton classification
Schematic of fluoro-electrochemical microscopy. (a) Cartoon E. huxleyi is green under normal light, but (b) emits red fluorescence under UV. (c) Placed near an oxidizing electrode, its fluorescence fades and ultimately (d) “switches off”.
Chem. Sci., 2023,14, 5872-5879
https://doi.org/10.1039/D3SC01741A
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Probing juxtaposed G-quadruplex and hairpin motifs using a responsive nucleoside probe: a unique scaffold for chemotherapy
We report the use of a new dual-app nucleoside probe composed of environment-sensitive fluorescent and 19F NMR labels in dissecting the structural polymorphism of G-quadruplexes formed by the EGFR gene, which is implicated in many cancers.
Chem. Sci., 2023,14, 5627-5637
https://doi.org/10.1039/D3SC00519D
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Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP5
We report the first molecular probe for the selective detection of the most abundant cellular inositol pyrophosphate 5-PP-InsP5, supported by computational chemistry, as well as an efficient new synthesis.
Chem. Sci., 2023,14, 4979-4985
https://doi.org/10.1039/D2SC06812E
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A modular aldol approach for internal fluorescent molecular rotor chalcone surrogates for DNA biosensing applications
Insertion of an indanone handle into DNA oligonucleotides permits base-catalyzed aldol to create fluorescent molecular rotor (FMR) chalcones with turn-on fluorescence and brightness suitable for biosensing applications.
Chem. Sci., 2023,14, 4832-4844
https://doi.org/10.1039/D3SC00772C
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Monitoring amyloid aggregation via a twisted intramolecular charge transfer (TICT)-based fluorescent sensor array
This work presents an integrative framework for optimizing organic fluorophores' TICT tendency and environmental sensitivities towards various applications. Two newly developed probes could detect the early phase of Aβ aggregation.
Chem. Sci., 2023,14, 4786-4795
https://doi.org/10.1039/D2SC06710B
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Tuning oxidative modification by a strong electric field using nanoESI of highly conductive solutions near the minimum flow rate
On-demand tunable oxidation is performed during the nanoESI-MS analysis by varying the nanoflow rate and the initial droplet size. The oxidation is initiated when the electric field of the droplet reaches ∼1.3 V nm−1.
Chem. Sci., 2023,14, 4506-4515
https://doi.org/10.1039/D2SC07113D
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Bent-to-planar Si-rhodamines: a distinct rehybridization lights up NIR-II fluorescence for tracking nitric oxide in the Alzheimer's disease brain
We report a configuration-dependent strategy to construct bent-to-planar NIR-II fluorophores, based on an innovative rehybridization fluorogenic building block, showing promise for illuminating biological events with high spatio-temporal resolutions.
Chem. Sci., 2023,14, 4091-4101
https://doi.org/10.1039/D3SC00193H
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All-in-One digital microfluidics pipeline for proteomic sample preparation and analysis
The All-in-One digital microfluidic pipeline allows for end-to-end automation of processing and analysis of mass-limited proteomic samples.
Chem. Sci., 2023,14, 2887-2900
https://doi.org/10.1039/D3SC00560G
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Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells
We designed two functionalized tetrahedral DNA nanostructures (f-TDN1 and f-TDN2), which could assemble into giant DNA networks triggered by APE1, achieving sensitive detection and intracellular imaging of APE1 as well as gene therapy.
Chem. Sci., 2023,14, 2318-2324
https://doi.org/10.1039/D2SC06968G
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The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination
A compact and clamped CHA-control-HCR (CCH) circuitry system, specifically for amplified multi-microRNA imaging, is developed to precisely distinguish cancer cells from normal cells.
Chem. Sci., 2023,14, 2159-2167
https://doi.org/10.1039/D2SC05568F
About this collection
This specially curated collection pulls together some of the most popular articles from 2023 in the field of analytical chemistry. The collection presents some outstanding contributions to the field, including chemical sensors for imaging total cellular aliphatic aldehydes in live cells and an all-in-one digital microfluidic pipeline for proteomic sample preparation and analysis. As with all Chemical Science articles, this collection is completely free to access and read. We hope you enjoy browsing through this collection.
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